Increased Intestinal Permeability Precedes Clinical Onset of Type 1 Diabetes
Studies were excluded if the primary or secondary outcomes did not include a scalp-specific measurement or if the full text could not be obtained
Discussion Despite several studies into the biology and genetics of hair greying or canities, the mechanism by which human scalp hairs lose pigmentation remains poorly understood, due in part to the complexity of interaction between different cell types, complex protein interactions, differential gene expression during the hair growth cycle, and variable conditions that occur within the hair follicle microenvironment 1,7,8,9,10,13,41,60,69,70,71,72,73,74
Importantly, a recent cost-effectiveness analysis using a Markov decision model showed that total thyroidectomy may be both more effective and less costly over the long term than continued medical therapy in euthyroid HT patients with disabling symptoms (58)
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