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The later finding that an oxidation event early in G1 phase is a critical regulatory step in the progression to S phase, lead to the development of the model of redox cycle within the cell cycle

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Their active redox centers have heme, cysteine thiols, selenium, manganese, and other chemical moieties

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When the concentration of MI is reduced in the follicular fluid (which is the case of PCOS, where it is reduced by 500 times), epimerase activation is excessive leading to an excess of DCI, an increase in insulin resistance and an increase in LH levels