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Furthermore, the osteoprotegerin (OPG)/Receptor Activator of Nuclear Factor B Ligand (RANKL) pathway is regulated by GLP-1RAs, increasing the OPG/RANKL ratio to inhibit osteoclast formation and promote bone formation by upregulating osteogenic genes like OC, COL1, Runx2, and ALP [120, 121]

Despite these promising findings, long-term clinical data remains limited

Our study suggests that besides obesity and diabetes, GLP-1-agonists may also help in the treatment of alcohol and substance use disorders

Cardiovascular effects of testosterone replacement therapy in hypogonadal men: a systematic review of lipid profiles, inflammatory markers, and vascular function

doi: 10.1136/bmjopen-2011-000494

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