Incretin mimetics have demonstrated safety and efficacy in advanced kidney disease, however multiple studies have shown that use of GLP1-RA have shown improvements in glycemic control, body weight reductions, improved beta cell function, and decreased incidence hypoglycemia as compared to DPP4i in a general diabetes population 26,27,28,29,30,31 , effects which might explain the reduction of acute healthcare utilization observed in this study of patients with CKD treated with GLP1-RA as compared to DPP4i
Some practitioners extend titration even further for particularly sensitive individuals
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That kind of rapid uptake is helping to drive pharmacy spending higher for employers and public plans across the country, even as clinicians continue to point to the benefits of GLP-1s for diabetes management
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