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The herbal medicine which he was consuming contained senna, which is an anthraquinone laxative and is notorious to cause melanosis coli

NSAIDs like ibuprofen are generally not recommended alongside isotretinoin without medical guidance

Abstract S -Alk(en)yl-L-cysteine sulfoxides are pharmaceutically important secondary metabolites produced by plants that belong to the genus Allium

Erastin can mediate ferroptosis through mitochondrial voltage-gated anion channels (VDAC) and xCT, which impairs VDAC function, thereby resulting in mitochondrial dysfunction, ROS production, and cell death [120]

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doi:10.1016/S0197-0186(00)00031-0