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J Biol Chem 294:1477614802

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Today, tirzepatide carries similar or identical warnings against severe side effects on its FDA labels

Ingestion of 5 g or more of Napa may lead to liver damage if the patient has following risk factors: If the patient is on long term treatment with Carbamazepine, Phenobarbitone, Phenytoin, Primidone, Rifampicin, St Johns Wort or other drugs that induce liver enzymes, or regularly consumes Ethanol in excess of recommended amounts, or is likely to be Glutathione deplete e.g

WHWT helped with human studies design and oversight

But starting one of these medications is only part of the picture