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Concretely, lactylation of NEDD4, a negative regulator of Caspase-11, impedes Caspase-11 ubiquitination by decreasing its interaction with Caspase-11, thereby triggering pyroptosis in macrophages and exacerbating acetaminophen-induced liver injury (AILI)

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Second, among patients with an active supply of AOM tirzepatide, we evaluated the distribution of GLP-1 use in the following month