10.1016/j.ecl.2020.11.001 Endocrinol Metab Clin North Am
Discussion Across nature, diminished growth factor signaling is linked to improved longevity 12
While moderate ROS boosts antimicrobial responses via NLRP3 inflammasome activation, uncontrolled mtROS exacerbates tissue injury, as observed in severe viral pneumonia, tuberculosis granulomas, and systemic candidiasis ( In contrast, pathogen-specific strategies reflect divergent evolutionary pressures
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