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Triple agonists add glucagon receptor activation, which: Increases resting energy expenditure by 8% to 12% (Jall et al., Diabetes Care 2024) Promotes hepatic fat oxidation and reduces steatosis May offset some of the lean mass loss seen with GLP-1 monotherapy (early signal, not yet confirmed in long-term trials) The weight loss ceiling for retatrutide appears to be 24% to 26% based on phase 3 data, though long-term real-world outcomes are not yet available

Department of Biomedical Sciences, Faculty of Veterinary Medicine, University of Prince Edward Island, Charlottetown, United States

E., Crouse, C

Finally, one study has found evidence for an interaction between a polymorphism at the Slc1A1 locus and a locus on chromosome 14 in determining risk for hoarding symptoms (Liang et al., 2008)