A mouse was placed at the center of the maze under an opaque beaker for 10 s
AEs of special interest identified by the sponsor and/or by clinical experts included injection-site reactions (as previously described), anaphylaxis, bradycardia, hyperpigmentation, melanoma, sexual events, and select psychiatric events, including anxiety, depression, suicidal ideation, suicide attempts, and aggression
Dihexa or its analogs were administered 5 minutes after scopolamine, either intracerebroventricularly at doses of 0.1 or 1 nmol), intraperitoneally at doses of 0.05, 0.25, or 0.50 mg/kg, or orally at doses of 1.25 or 2.0 mg/kg
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Clinical studies have shown that, when used under the guidance of a qualified healthcare professional, GLP-1 medications can provide significant and lasting weight loss results with a favorable safety profile
Yang PY, Zou H, Lee C, Muppidi A, Chao E, Fu Q, Luo X, Wang D, Schultz PG, Shen W (2018) Stapled, long-acting glucagon-like peptide 2 analog with efficacy in dextran sodium sulfate induced mouse colitis models