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Additionally, while FOXO4-DRI has been shown to limit chemotoxicity in certain contexts, its overall safety profile in humans requires further research to fully understand all potential side effects

Old gynecomastia, where tissue has become fibrotic, is not going to respond significantly to drugs alone and may still require excision

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In conclusion, our results suggest that supplementation of l-carnitine and selenium is important for PKU patients since it could help to correct the oxidative stress process which possibly contributes, at least in part, to the neurological symptoms found in phenylketonuric patients

Hollyer T, Boon H, Georgousis A, et al