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LTF also increases the activity of cathepsin G, a known antibacterial enzyme (66), and broadens its substrate specificity (67), suggesting that LTF acts in concert with antibacterial neutrophil-derived enzymes in the initial phase of infection

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Long-term studies and clinical trials indicate that patients who continue treatment with these medications, along with adherence to recommended lifestyle changes, are more likely to maintain significant weight loss compared to those who discontinue the medication

In conclusion, these findings indicate that IF may offer a valuable non-pharmacological approach to managing rheumatoid arthritis in this specific population, addressing both the primary disease symptoms and associated metabolic complications

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