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Tirzepatide (a GLP-1R/GIPR dual agonist), licensed by the MHRA as Mounjaro for type 2 diabetes and, subject to NICE guidance, for weight management in adults with obesity, achieved mean weight reductions of up to approximately 22% in the SURMOUNT-1 trial (NEJM 2022) a notable improvement over GLP-1R monotherapy

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Additionally, our findings on glutathione antioxidant pathway suggest ozone therapy up regulated the antioxidant defense system counteracting the oxidative stress produced from the inflammatory mediators

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