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595 Cipriani, M
In the identification step, original articles, in addition to reviews, were evaluated in full text to identify references that may have been missed by our search strategy
Some individuals report noticeable changes after 48 weeks , although results vary depending on diet, exercise, and metabolism
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A novel miR-338-3p/SLC1A5 axis has been identified as a key regulator of oxidative stress-induced ferroptosis in DR: high glucose significantly upregulates miR-338-3p expression in RPE cells, and miR-338-3p silencing reverses RPE cell death and ferroptosis ( Although studies have confirmed that the three components form a positive-feedback loop that drives DR progression and that antioxidant therapy can alleviate DR pathology, the key molecular triggers that initiate the loopsuch as the cell-specific mechanisms by which hyperglycemia induces excessive ROS production in different retinal cellsremain poorly defined
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