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Int J Obes (Lond) 49:433451

US Food and Drug Administration (2021) Rybelsus : highlights of prescribing information

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Red flags requiring immediate evaluation include severe abdominal pain (possible pancreatitis), persistent vomiting leading to dehydration, suicidal thoughts, development of new eating disorder behaviors, syncope, chest pain, hematemesis/melena, severe constipation/obstipation, orthostatic hypotension, or marked electrolyte abnormalities

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Do not inject more frequently than the minimum interval to compensate for the shift