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Nevertheless, the paired study design was adequately powered to determine clinically relevant changes in GPR and gluconeogenesis and the sample size was comparable with those of other stable isotope studies examining metformins in vivo glucose-lowering effects [8, 10,11,12,13]

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Are There Differences in Health Benefits Offered

These figures are notably higher than what is reported in studies that solely rely on patient-reported symptoms or hospitalisation records [19]