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This is achieved by the ability of erythrocytes to scavenge and detoxify exogenous neutrophils-, monocytes- or endothelial cells-derived reactive oxygen species (ROS) and reactive nitrogen species (RNS) [53, 54]

Factor XIIIa inhibitors Numerous synthetic and natural factor XIII (FXIII) inhibitors have been investigated in preclinical trials and in vitro studies

10.1111/j.1365-2133.2007.07779.x [DOI] [PubMed] [Google Scholar] 38.Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, et al

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One possible explanation for such a response is that inhibition of mTORC1 and activation of GCN2 collectively suppresses global translation to conserve nutrients, while selective translation of mRNA such as ATF4 (mediated by increased p-eIF2) activates the expression of AARE genes to mitigate cellular stress