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Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications

The primary mechanical barrier is formed by intestinal mucosal epithelial cells and tight junction proteins, while the chemical barrier includes mucus secreted by epithelial cells and antimicrobial substances produced by the gut microbiota, effectively preventing the invasion of bacteria and toxins, thereby mitigating severe inflammatory responses and endotoxemia (Neurath et al., 2025)

[DOI] [PubMed] [Google Scholar] 16.Lehner C., Gehwolf R., Tempfer H., Krizbai I., Hennig B., Bauer H.-C., Bauer H

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Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes

& Somanath, P