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Interestingly, inhibition of JAK/STAT signaling by ruxolitinib suppressed C/EBP transcriptional activity, leading to a reduction in systemic inflammation by SASP repression and improvement in fitness in elderly mice (94)

however, IPA supplementation effectively decreases viral load and mitigates both local (lung) and systemic inflammatory responses (92)

Documentation: Maintain precise records of dose, route, timing, and experimental conditions

If any adverse effects occur, contact a healthcare provider immediately

10.1136/bmjopen-2012-001986 139

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