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Diagnosis and management of glutaric aciduria type Irevised recommendations

353,354 Age-related increase in oxidative stress and cell senescence leads cells/tissues to be more prone to undergo necroptosis, thereby releasing DAMPs that trigger the chronic inflammation observed with aging

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Conditional GPX4 knockout mice exemplify the risks of single-pathway targeting: while GPX4 deletion in PT cells protects against early AKI by eliminating damaged cells, long-term deletion activates the cGASSTING pathwaylikely via release of fragmented mitochondrial DNAleading to sustained type I interferon signaling and progressive interstitial fibrosis

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