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Dehydration compounds these effects because semaglutide users already have reduced thirst signals

Baseline estimated renal function was normal (eGFR 90 mL/min/1.73m 2 ) in 66.2%, mildly impaired (eGFR 60 to 90 mL/min/1.73m 2 ) in 32.4% and moderately impaired (eGFR 30 to 60 mL/min/1.73m 2 ) in 1.4% of patients

Heterozygote littermates show no evidence of gross abnormality compared with WT mice suggesting that the INAD symptoms are inherited as an autosomal recessive trait in the same way as human INAD patients