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Ianculescu I, Wu DY, Siegmund KD, Stallcup MR

Formulation technology: The delivery vehicle - adhesives, penetration enhancers, and patch matrix design - can influence whether compounds meaningfully pass through the skin barrier

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We stated that if a manufacturer has determined that a fee paid meets the other elements of the definition of bona fide service fees, then the manufacturer may presume, in the absence of any evidence or notice to the contrary, that the fee paid is not passed on to a client or customer of any entity

This requires administration of a larger volume of liquid to ensure adequate drug dosing