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1 Introduction Intervertebral disc degeneration (IVDD) is the main contributor to the development of low back pain, leading to a remarkable loss of disability-adjusted life years as well as a substantial economic burden on society ( The healthy disc is not isolated from other tissues, despite having long been known as a unique organ without blood vessels, nerves, or immune cell infiltration ( In this review, we aimed to summarize the molecular and biochemical characteristics of organokines from specific tissues and their association with disc homeostasis and degeneration
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Differential metabolome in rheumatoid arthritis: a brief perspective
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