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Robust activity of avapritinib, potent and highly selective inhibitor of mutated KIT, in patient-derived xenograft models of gastrointestinal stromal tumors

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We analyzed SNPs ( APOE, CETP, MTHFR, F5 ), protein levels (CRP, IL-6, D-dimer, fibrinogen, NSE, S100B), gene expression ( MMP9, TIMP1, VEGFA, BDNF ), microRNAs (miR-124, miR-21, miR-145, miR-155), and neuroimaging features (lesion volume, location, ADC values)

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we monitored the local temperature changes in the joints of acute gout SD rats before and after treatment (Figure S14)