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When laminar shear stress is perturbed at curved sections of arteries, the bioavailability of NO decreases, leading to an increase of the O2 - levels (Reference Hosoya, Maruyama and Kang86) and a decrease of Nrf2-activated genes, which results in a predisposition of the endothelium to atherogenesis (Reference Cheng, Siow and Mann87)

However, very high doses taken for extended periods may increase the risk of mild gastrointestinal symptoms

Groen, H

But while Rogan is best known for being open and honest on his own podcast, The Joe Rogan Experience, Rogans comments come from being a guest on the Flagrant 2 podcast

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This specialized blend of vitamins, antioxidants, and essential nutrients is designed to nourish your skin, promote collagen production, and leave you with a luminous glow