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All mechanistic and pharmacological findings are derived from short-duration preclinical models only
WEIGHT GAIN In the UKPDS, sulfonylurea treatment caused a net weight gain of approximately 3 kg, which occurred during the first 3-4 years of treatment and then stabilized (21,34)
In MAA, the anagen phase decreases with each cycle, while the length of telogen remains constant or is prolonged
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In progressively older patient groups experience in epilepsy has indicated that the incidence of fatal hepatotoxicity decreases considerably
Conclusion Semaglutide and Tirzepatide represent two important approaches to incretin-based research
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