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Toxicity from B12-derived cyanide has never been documented even with mega-dose supplementation

XZ: Writing original draft, Data curation, Formal Analysis

And some people seem to believe Alzheimers or dementia are metabolically activated

The challenge is ensuring you still consume adequate nutrition, particularly protein

Petrie JR, Chaturvedi N, Ford I et al (2017) Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

For subgroup analysis, the studies were classified based on whether the control group received metformin or placebo