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In a rat model of arthritis, synovial pannus cells increase glucose uptake 42 , and HK2, a rate-limiting enzyme of glycolysis, regulates the aggressive functions of FLS 21

As GLP-1 agonists have garnered attention for management of obesity due to their effect on reducing insulin sensitivity, they are now being considered a therapeutic option for the treatment of PCOS (polycystic ovarian syndrome), one of the most common causes of subfertility, diagnosed via Rotterdams criteria: oligomenorrhea, hyperandrogenism and polycystic ovaries (97)

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A study has shown that high expression of DPP-4 is not only found in intestinal epithelial brush border, but also in endothelial cells ( via renal elimination

However, theres an important caveat: most of the data comes from animal research, not human clinical trials

doi:10.3390/ijms19092505 94