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Neurogenesis, synaptic plasticity, and metabolic support GLP-1R stimulation promotes hippocampal neurogenesis and enhances synaptic plasticity, partly through brain-derived neurotrophic factor and modulation of glutamatergic signalling

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(Shanghai, China) and randomly assigned into five groups: the non-treatment control group, the high-fat diet (HFD)/streptozotocin (STZ)-induced T2DM group, the STZ-induced T2DM plus sham surgery group, the STZ-induced T2DM plus RYGB surgery group, and the STZ-induced T2DM plus EX-4 treatment group

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Researchers surmise that CJC-1295, as a derivative of GHRH, may offer the same benefits by mimicking the dual neuronal and endocrine function of hypothalamic GHRH activity [8, 9]

Mechanisms of Disease: hepatic steatosis in type 2 diabetespathogenesis and clinical relevance