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MPTP undergoes enzymatic modification in the brain to form MPP+, a neurotoxic compound that interrupts the electron transport system of dopaminergic neurons

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MS2 spectra were acquired in the linear ion trap with a 0.7 Da isolation window, CID fragmentation energy of 35%, turbo scan speed, 50 ms max inject time, 1 10 4 automatic gain control (AGC) and maximum parallelizable time turned on 17

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High-resolution ferroptosis atlases integrating emerging technologies such as single-cell omics, spatial transcriptomics, and MRImass spectrometry fusion platforms are urgently needed to delineate these dynamics (Currais et al., 2025)