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For example, in the case of amylin biology, significant translational gaps between rodent and human systems persist, the optimal receptor selectivity profile for clinical use remains unclear, and molecules continue to advance in clinical development despite these uncertainties ( 3.4 Changing clinical and regulatory expectations Finally, shifts in clinical and regulatory expectations have altered the landscape in which peptide therapeutics are evaluated

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Given its GLP-1 activity, similar reward-modulating effects are plausible, but unproven

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The gastrointestinal tract as an integrator of mechanical and hormonal response to nutrient ingestion