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Early data suggest complementary effects when both agents are metabolically relevant, but robust clinical trials are ongoing

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Antioxidants (Basel) (2020) 9:E810

It is used to treat anxiety in adults and major depressive disorder in adults and adolescents who are at least 12 years old

Cochrane systematic reviews of dietary supplement interventions emphasize that ingredient-level findings don't automatically translate to whole-formula outcomes, and that patch-delivery-specific human trials in this category are absent from the published literature