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Preserving 10 pounds of muscle during weight loss maintains approximately 40 to 50 extra calories of daily expenditure

Participants completed original and adapted forms of validated assessments (see Supplemental document)

The active product and corresponding placebo product were visually identical to maintain masking of participants and site staff

Generic protocols work for many people, but optimization requires personalized adjustments based on your unique response patterns

The subcutaneous fat layer acts like a sponge

It forces the system to recalibrate again, often producing renewed weight loss in people who had completely stalled on compounded tirzepatide