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In people with normal absorption, deficiencies have been reported only in strict vegetarians who consume no products of animal origin (including no milk products or eggs)

If serum B12 is 300500 pg/mL with elevated MMA, you have subclinical deficiency that warrants treatment

B-12 - contraindicated in Lebers disease (optic atrophy)

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Youll often find that the recommended daily intake (RDI) for B12 listed as 2.4 mcg (SOURCE, SOURCE) for most men, and women over the age of 19 (the RDI for pregnant women is 2.6 mcg), but recent evidence suggests that 4-7 mcg might be better (SOURCE)