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If it's a mild side effect, you know, like you have a little bit of reflux, you have a little, it's not major, but you can, you feel like a little off, then it is worth pushing because a lot of people find after four to six weeks that it starts to shift, that those side effects tend to dissipate

A.DucrosV.JeandelC.JuliaC.HercbergS.et al (2014)

Real-World Effectiveness Analysis of Switching From Liraglutide or Dulaglutide to Semaglutide in Patients With Type 2 Diabetes Mellitus: The Retrospective REALISE-DM Stud

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It depends on the details of your plan

FOXO4-DRI may inhibit the FOXO4 translocation to the nucleus, potentially reducing oxidative stress defenses but primarily in senescent cells