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Since 90% of the bodys serotonin originates in the gut, these peripheral effects could influence central serotonergic tone through vagal signaling

[Effect of N-Acetylcysteine on Cognitive Function and Nuclear Factor Erythroid 2 Related Factor 2/Heme Oxygenase-1 Pathway in Mouse Models of Postoperative Cognitive Dysfunction] Zhongguo Yi Xue Ke Xue Yuan Xue Bao

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Commenters expressed concern that removing the measure could reduce institutional accountability and preparedness, ultimately resulting in higher costs associated with preventable infections

229 Although evolved to sense metals or metal-complexes directly, the set-point or sensitivity of these riboswitches to bioavailable metal may not fully align with the set-point of the analogous protein-based sensors given the complexity of the regulatory response involved (Section 3.3)