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In a 4-week controlled trial of VYVANSE in pediatric patients ages 13 to 17 years, mean weight loss from baseline to endpoint was -2.7, -4.3, and -4.8 lbs., respectively, for patients receiving 30 mg, 50 mg, and 70 mg of VYVANSE, compared to a 2.0 pound weight gain for patients receiving placebo

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Significant or rapid weight loss, especially without proper dietary guidance and activity, can lead to disproportionate muscle loss and even reductions in bone density, which can have long-term health implications, particularly for older adults

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