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When weight loss exceeds 1.5 kg (approximately 3 pounds) per week, bile composition changes: cholesterol becomes supersaturated while bile salts and lecithin decrease, creating conditions favorable for stone formation

[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Courtemanche C, Elson-Schwab I, Mashiyama ST, et al

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Although some studies have shown that obesity-induced histone alterations could be reversed, the persistence of some modifications have been established