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That means: Your body also develops a tolerance to the GI side effects over time, which is why patients who start carefully can tolerate higher doses later in treatment that would have been overwhelming at week one

doi:10.1007/s00213-024-06735-1

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Several studies have shown that PPAR is a major regulator of adipogenesis and that the maintenance of its expression is essential for the progression through the late stages of differentiation [25]

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