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Upon induction of hypoxia, HIF1 is no longer polyubiquitinated and can form a functional heterodimer with HIF1, allowing it to translocate to the nucleus and induce transcription (261)

Overall discontinuation rates due to adverse events were low at 5.9% for CagriSema vs 3.5% for placebo

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Most common adverse reactions included diarrhea, decreased appetite, emesis, lethargy, weight loss and neutropenia

Appl Microbiol Biotechnol 101:56675675