Orlistat reduces fat absorption but can cause digestive side effects, while SGLT2 inhibitors, used in type 2 diabetes, tend to produce only modest weight loss while helping protect the heart and kidneys
This helps explain why diabetes is strongly associated with coronary heart disease and stroke
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The subject's ability to tan, rather than burn, is markedly improved, which is often the core objective of such studies
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these variations might also explain the difference in cardiovascular effect observed in large-scale cardiovascular outcome trials, in which certain GLP1RAs were shown to have a positive effect on cardiovascular outcomes