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Study end points The primary endpoint was the percentage of total body weight loss (TBWL%) at 12 months after semaglutide initiation by HT use

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FYI, Rybelsus also contains semaglutide and is FDA-approved for type 2 diabetes

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Gastrointestinal Effects GLP-1 medications have significant effects on the digestive system: They slow stomach emptying, increasing feelings of fullness They reduce gastric acid production They may help with inflammatory bowel diseases They enhance gut barrier protection They have anti-inflammatory effects in the digestive tract While these effects help with weight loss and blood sugar control, they can also cause side effects like nausea, vomiting, and diarrhea