The combination addresses both insulin resistance (metformin) and appetite dysregulation (semaglutide), which is why it's considered first-line for many patients with metabolic syndrome
It also has potential in treating rare neurodegenerative disorders, such as spinocerebellar ataxias, by reducing polyglutamine protein aggregation and improving protein quality control systems, and hereditary spastic paraplegias by improving mitochondrial function and axonal transport [93]
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