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while all three treated groups had benefits as assessed by looking at liver fat area and triglycerides, the Sema + -MSTN/-ActA combination (which had the largest decreases in overall body fat composition) also had the largest benefits in terms of these liver measures (Fig

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In contrast, a global pharmacovigilance study did report a significant and disproportionate association between semaglutide and reports of ischemic optic neuropathy (including NAION) [117]