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Fifteen years ago, researchers showed that low doses of oral cyclobenzaprine (3-4 mg) at bedtime reduced the alpha-EEG and mildly improved fibromyalgia pain

After an initial loading regimen of 1mg three times weekly for two weeks, maintenance therapy is typically 1mg every three months for life in conditions like pernicious anaemia, or every two months if neurological involvement was present

Cognitive Enhancement By promoting synaptic plasticity and hippocampal neurogenesis, PE-22-28 is studied for its ability to improve spatial memory and learning capabilities in models of cognitive decline

In terms of side effects and tolerability, the advantage goes to PE-22-28

1718-1730, Li, Guangqi, et al

It contains a cyanide molecule, which the FDA considers safe for healthy individuals