doi: 10.3389/fmicb.2021.656809 40 KnstlerA.KtayG.GullnerG.KirlyL
In the TMLHE gene knockout mouse model, the carnitine biosynthetic pathway is inhibited due to the loss of TMLD activity in the liver, affecting the availability of carnitine in the heart, significantly reducing the rate of synthesis of LCACs, and contributing to the protection of mitochondrial function after myocardial IRI [215]
These findings support the idea that MOTS-C could offset the exercise intolerance and fatigue that sometimes accompanies aggressive caloric restriction from Retatrutide
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Off-label uses include weight loss, management of insulin resistance, and sometimes for conditions like PCOS under medical supervision
Nature 485 , 459464 (2012)