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C., Miller, E

In terms of side effects and tolerability, the advantage goes to neither (comparable)

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Over time, obese patients lose roughly 12% of their body weight on Wegovy (semaglutide) and about 18% on Zepbound (tirzepatide, which targets GLP-1 and another gut hormone, GIP.) Diana Thiara, MD, medical director of the UCSF Weight Management Program, says the results can be amazing and life-changing for people with obesity, a condition linked to a host of health risks

Bulletin of Experimental Biology and Medicine, 137 (5), 510512