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The corresponding IC50 values for the oxazole derivative 46 with the extended P1 side chain were 35 and 57 nM, respectively ( 45 (DG046) in the closed-conformation of ERAP1 was disclosed ( In 2015, 47 exhibited the best IRAP inhibitory capacity (IC50 = 105 nM) and demonstrated an almost 10-fold selectivity vs

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