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MOTS-C is a mitochondrial-derived peptide with laboratory research suggesting metabolic effects

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NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

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There is a complex pathophysiological interaction between T2DM and osteoporosis

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