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Finally, we identified 15 eligible studies for inclusion (9 RCTs on GLP-1 RAs in T2DM, 21,29 36 2 post-hoc analyses of RCTs on GLP-1 RAs, 37,38 4 RCTs on tirzepatide in T2DM 39 42 ), comprising a total of 65,878 T2DM patients

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10 The results from various studies indicated that incretin-based therapies such as exenatide, liraglutide, and semaglutide were able to improve clinical outcomes through decreasing neuroinflammation, increasing neuroprotection, and enhancing cognition

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